Louise Ryan
Professor of Biostatistics
Department of Biostatistics

Contact Information

    Department of Biostatistics
    Building II
    4th Floor, Room 409
    655 Huntington Avenue
    Boston, MA 02115
    Phone: 617-432-4902
    Fax: 617-739-1781
    Email: lryan@hsph.harvard.edu

Education

    Ph.D., 1983, Harvard University

Research Interests
    Dr. Ryan works on statistical methods related to environmental risk assessment for cancer, developmental and reproductive toxicity, and other non-cancer endpoints such as respiratory disease. She also works on cancer clinical trials and epidemiological methods for the study of birth defects and adverse reproductive outcomes. A special interest is the analysis of multiple outcomes as they occur in these applied settings. Recently, Dr. Ryan has developed interests in community based environmental health research. This interest has arisen, in part, from her involvement as a technical advisor to a citizens' group on Cape Cod, who are concerned with high cancer rates in that community. Dr. Ryan has also worked on a study to assess air quality in the Dudley Square region of Boston. One of Dr Ryan's current projects involves a collaboration with Dr Rosalind Wright from Channing Laboratory (HMS), who is conducting a study in East Boston to assess possible connections between chronic stress, particularly that associated with exposure to violence, and the onset and exacerbation of asthma.

    Dr. Ryan also works with the Eastern Cooperative Oncology Group on the design, implementation, analysis and reporting of clinical trials for a variety of different types of cancer. Dr. Ryan's specialties are GI cancer and sarcoma. Dr. Ryan works on statistical methods for clinical trials, in particular, survival analysis techniques for competing risk data.

    Dr. Ryan is a fellow of the American Statistical Association and in the International Statistics Institute. She is currently a co-editor of Biometrics and President of the Eastern North American Region of the International Biometric Society. She has served on advisory boards for several government agencies, including the National Toxicology Program and the Environmental Protection Agency, as well as several committees for the National Academy of Science.

 
 
Select Publications
    Geys H, Molenberghs G, Ryan LM. "Pseudolikelihood modeling of multivariate outcomes in developmental toxicology." Journal of the American Statistical Association, 1999; 94:734-745.

    Weller E, Long N, Smith A, Williams P, Ravi S, Gill J, Henessey R, Skornik W, Brain J, Kimmel C, Kimmel G, Holmes L, Ryan LM. "Dose-rate effects of ethylene oxide exposure on developmental toxicity." Toxicological Sciences, 1999; 50:259-270.

    Betensky RA, Lindsey JC, Ryan LM, Wand MP. "Local EM estimation of the hazard function for interval-censored data.'' Biometrics. 1999; 55:238-245.

    Sammel MD, Lin LM, Ryan LM. "Multivariate linear mixed models for multiple outcomes." Statistics in Medicine, 1999; 18:2479-2492.

    Brumback BA, Holmes LB, Ryan LM. "Adverse effects of chorionic villus sampling: a meta-analysis." Statistics in Medicine, 1999; 18:2163-2175.

    Weller EA, Ryan LM. "Testing for trend with count data." Biometrics, 1998; 54:762-773.

    Ibrahim JG, Ryan LM, Chen MH. "Use of historical controls to adjust for covariates in trend tests for binary data." Journal of the American Statistical Association, 1998; 93:1282-1293.

    Sammel MD, Ryan LM, Legler JM. "Latent variable models for mixed discrete and continuous outcomes." Journal of the Royal Statistical Society, Series B, 1997; 59:667-678.

Web Site(s)
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